Simple little tip. This is one for the times you scratch your head after configuring EWS with what seems like a simple URL change (eg https://mail.consultantsrus.co.uk/ews/exchange.asmx). You are sure it is correct, and you have done an IISRESET on all your CAS servers. But still when you connect via Outlook Anywhere you get the annoying "Mailtips cannot be retrieved" on a new message, and the Out of Office cannot be set with the "server is not available" warning.
Go back into IIS and recycle the Autodiscover app pool ! Voila ! Simples :-)
Hope this helps